Treatment will depend on your child’s symptoms, age, and general health. How is X-linked agammaglobulinemia treated in a child? Your child may need many blood tests to help confirm the diagnosis. The provider will give your child a physical exam. He or she may also ask about your family’s health history. The healthcare provider will ask about your child’s symptoms and health history. How is X-linked agammaglobulinemia diagnosed in a child? Make sure your child sees his or her healthcare provider for a diagnosis. The symptoms of this disease may be like other health conditions. Skin and muscle inflammation (dermatomyositis)Ī few older children with this disease may have cancers such as leukemia, lymphoma, or colon cancer. Joint disease, mainly in the knees, similar to juvenile rheumatoid arthritisīreakdown of red blood cells (autoimmune hemolytic anemia)įewer white blood cells called neutrophils (neutropenia) Many serious or life-threatening illnesses such as infections of the nasal passages, skin, eyes, bones, lungs, digestive tract, and bloodstream But they can also show up as late as age 3 to 5 years. The symptoms of this disease usually show up in the first 6 to 9 months of age. What are the symptoms of X-linked agammaglobulinemia in a child? If a son gets the gene, he will have X-linked agammaglobulinemia. If a daughter gets the gene, she will likely be a healthy carrier like her mother. Women who are carriers have a 1 in 2 chance of passing the faulty X chromosome to a child. Which children are at risk for X-linked agammaglobulinemia? This can happen if there is a new change (mutation) on the child’s X chromosome before birth. In some cases, a child may have the faulty gene without inheriting it. If their X chromosome carries a faulty gene they will have symptoms. Girls can have the faulty gene on 1 of their X chromosomes but not have any symptoms of the disease. The pair is 1 X and 1 Y chromosome for males. This pair is 2 X chromosomes for females. The 23rd pair controls a person’s gender. People normally have 23 pairs of chromosomes in each cell of their body. X-linked agammaglobulinemia is caused by a faulty gene on the X chromosome. What causes X-linked agammaglobulinemia in a child? Most children with this disease who are treated early can lead normal, active lives. The infections can also involve the bloodstream or internal organs. So a child with this disease can’t fight off infections caused by bacteria and by some viruses.īoys with this disease are more likely to get infections in the middle ear, sinuses, and lungs. Antibodies are the body's main defense against germs like bacteria and viruses. It mainly affects boys, because they have only have one X chromosome.Ī child with this disease can’t make antibodies that are part of gamma globulins in blood plasma. X-linked means that the gene that causes this disease is located on the X chromosome. It is also known as Bruton's agammaglobulinemia. X-linked agammaglobulinemia is a rare genetic disease. X-Linked Agammaglobulinemia in Children What is X-linked agammaglobulinemia in children?
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